The Atkinson Building is an historic commercial building at 220 Lisbon Street in Lewiston, Maine, United States. Erected in 1892, the six-story Romanesque style building was the tallest in the city at the time, and is still an imposing presence in the city's central business district. It was designed by Auburn architect Elmer I. Thomas to harmonize with the adjacent Lewiston City Hall, and is one of its finest Victorian commercial buildings. It was listed on the National Register of Historic Places in 1983.